function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =65; end % There are a total of 15 entries in each of the rate and state variable arrays. % There are a total of 39 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('t in component environment (second)'); LEGEND_STATES(:,1) = strpad('q_Ca_i in component environment (fmol)'); LEGEND_STATES(:,2) = strpad('q_Ca_SR in component environment (fmol)'); LEGEND_STATES(:,3) = strpad('q_H_i in component environment (fmol)'); LEGEND_STATES(:,4) = strpad('q_Pi in component environment (fmol)'); LEGEND_STATES(:,5) = strpad('q_MgADP in component environment (fmol)'); LEGEND_STATES(:,6) = strpad('q_MgATP in component environment (fmol)'); LEGEND_STATES(:,7) = strpad('q_P1_SERCA in component environment (fmol)'); LEGEND_STATES(:,8) = strpad('q_P2_SERCA in component environment (fmol)'); LEGEND_STATES(:,9) = strpad('q_P2a_SERCA in component environment (fmol)'); LEGEND_STATES(:,10) = strpad('q_P4_SERCA in component environment (fmol)'); LEGEND_STATES(:,11) = strpad('q_P5_SERCA in component environment (fmol)'); LEGEND_STATES(:,12) = strpad('q_P10_SERCA in component environment (fmol)'); LEGEND_STATES(:,13) = strpad('q_P6_SERCA in component environment (fmol)'); LEGEND_STATES(:,14) = strpad('q_P8_SERCA in component environment (fmol)'); LEGEND_STATES(:,15) = strpad('q_P9_SERCA in component environment (fmol)'); LEGEND_CONSTANTS(:,1) = strpad('q_PLBp in component environment (fmol)'); LEGEND_CONSTANTS(:,2) = strpad('q_PLBp_baseline in component environment (fmol)'); LEGEND_ALGEBRAIC(:,52) = strpad('v_Ca_i_SERCA in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,58) = strpad('v_Ca_SR_SERCA in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,63) = strpad('v_H_SERCA in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,49) = strpad('v_MgADP_SERCA in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,46) = strpad('v_MgATP_SERCA in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,44) = strpad('v_Pi_SERCA in component SERCA (fmol_per_sec)'); LEGEND_CONSTANTS(:,3) = strpad('kappa_SERCA_R1_2 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,4) = strpad('kappa_SERCA_R2_4 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,5) = strpad('kappa_SERCA_R2_2a in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,6) = strpad('kappa_SERCA_R4_5 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,7) = strpad('kappa_SERCA_R5_6 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,8) = strpad('kappa_SERCA_R6_8 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,9) = strpad('kappa_SERCA_R8_9 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,10) = strpad('kappa_SERCA_R9_10 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,11) = strpad('kappa_SERCA_R10_1 in component SERCA_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,12) = strpad('K_P1_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,13) = strpad('K_P2_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,14) = strpad('K_P2a_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,15) = strpad('K_P4_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,16) = strpad('K_P5_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,17) = strpad('K_P6_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,18) = strpad('K_P8_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,19) = strpad('K_P9_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,20) = strpad('K_P10_SERCA in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,21) = strpad('K_H in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,22) = strpad('K_Ca_i in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,23) = strpad('K_Ca_SR in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,24) = strpad('K_MgATP in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,25) = strpad('K_MgADP in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,26) = strpad('K_Pi in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,27) = strpad('K_PLBp in component SERCA_parameters (per_fmol)'); LEGEND_CONSTANTS(:,28) = strpad('R in component constants (J_per_K_per_mol)'); LEGEND_CONSTANTS(:,29) = strpad('T in component constants (kelvin)'); LEGEND_CONSTANTS(:,30) = strpad('F in component constants (C_per_mol)'); LEGEND_CONSTANTS(:,31) = strpad('n_Ca_i in component SERCA (dimensionless)'); LEGEND_CONSTANTS(:,32) = strpad('n_Ca_SR in component SERCA (dimensionless)'); LEGEND_CONSTANTS(:,33) = strpad('n_H in component SERCA (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('q_SERCA_Ca_complexes in component SERCA (fmol)'); LEGEND_ALGEBRAIC(:,2) = strpad('c_Ca_i in component SERCA (mM)'); LEGEND_ALGEBRAIC(:,3) = strpad('c_Ca_SR in component SERCA (mM)'); LEGEND_ALGEBRAIC(:,4) = strpad('c_H in component SERCA (mM)'); LEGEND_ALGEBRAIC(:,5) = strpad('c_MgADP in component SERCA (mM)'); LEGEND_ALGEBRAIC(:,6) = strpad('c_MgATP in component SERCA (mM)'); LEGEND_ALGEBRAIC(:,7) = strpad('c_Pi in component SERCA (mM)'); LEGEND_CONSTANTS(:,34) = strpad('vol_i in component SERCA (pL)'); LEGEND_CONSTANTS(:,35) = strpad('vol_sr in component SERCA (pL)'); LEGEND_CONSTANTS(:,37) = strpad('vol_isr in component SERCA (pL)'); LEGEND_ALGEBRAIC(:,8) = strpad('mu_Ca_i in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,9) = strpad('mu_Ca_SR in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,10) = strpad('mu_H in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,11) = strpad('mu_MgADP in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,12) = strpad('mu_MgATP in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,14) = strpad('mu_P1 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,47) = strpad('v_P1 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,13) = strpad('mu_Pi in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,15) = strpad('mu_P2 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,54) = strpad('v_P2 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,16) = strpad('mu_P2a in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,51) = strpad('v_P2a in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,17) = strpad('mu_P4 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,56) = strpad('v_P4 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,18) = strpad('mu_P5 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,57) = strpad('v_P5 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,20) = strpad('mu_P6 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,60) = strpad('v_P6 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,22) = strpad('mu_P8 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,62) = strpad('v_P8 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,23) = strpad('mu_P9 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,64) = strpad('v_P9 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,19) = strpad('mu_P10 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,65) = strpad('v_P10 in component SERCA (fmol_per_sec)'); LEGEND_CONSTANTS(:,36) = strpad('mu_PLBp_baseline in component SERCA (J_per_mol)'); LEGEND_CONSTANTS(:,38) = strpad('mu_PLBp in component SERCA (J_per_mol)'); LEGEND_CONSTANTS(:,39) = strpad('mu_PLBp_eff in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,26) = strpad('Af_R1_2 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,27) = strpad('Ar_R1_2 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,43) = strpad('v_SERCA_R1_2 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,28) = strpad('Af_R5_6 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,29) = strpad('Ar_R5_6 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,45) = strpad('v_SERCA_R5_6 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,30) = strpad('Af_R2_2a in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,31) = strpad('Ar_R2_2a in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,48) = strpad('v_SERCA_R2_2a in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,32) = strpad('Af_R2_4 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,33) = strpad('Ar_R2_4 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,50) = strpad('v_SERCA_R2_4 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,34) = strpad('Af_R4_5 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,35) = strpad('Ar_R4_5 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,53) = strpad('v_SERCA_R4_5 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,36) = strpad('Af_R6_8 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,37) = strpad('Ar_R6_8 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,55) = strpad('v_SERCA_R6_8 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,38) = strpad('Af_R8_9 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,39) = strpad('Ar_R8_9 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,59) = strpad('v_SERCA_R8_9 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,40) = strpad('Af_R9_10 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,41) = strpad('Ar_R9_10 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,61) = strpad('v_SERCA_R9_10 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,24) = strpad('Af_R10_1 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,25) = strpad('Ar_R10_1 in component SERCA (J_per_mol)'); LEGEND_ALGEBRAIC(:,42) = strpad('v_SERCA_R10_1 in component SERCA (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,21) = strpad('v_SERCA_R10_1_noPLBp in component SERCA (fmol_per_sec)'); LEGEND_RATES(:,1) = strpad('d/dt q_Ca_i in component environment (fmol)'); LEGEND_RATES(:,2) = strpad('d/dt q_Ca_SR in component environment (fmol)'); LEGEND_RATES(:,3) = strpad('d/dt q_H_i in component environment (fmol)'); LEGEND_RATES(:,5) = strpad('d/dt q_MgADP in component environment (fmol)'); LEGEND_RATES(:,6) = strpad('d/dt q_MgATP in component environment (fmol)'); LEGEND_RATES(:,4) = strpad('d/dt q_Pi in component environment (fmol)'); LEGEND_RATES(:,7) = strpad('d/dt q_P1_SERCA in component environment (fmol)'); LEGEND_RATES(:,8) = strpad('d/dt q_P2_SERCA in component environment (fmol)'); LEGEND_RATES(:,9) = strpad('d/dt q_P2a_SERCA in component environment (fmol)'); LEGEND_RATES(:,10) = strpad('d/dt q_P4_SERCA in component environment (fmol)'); LEGEND_RATES(:,11) = strpad('d/dt q_P5_SERCA in component environment (fmol)'); LEGEND_RATES(:,12) = strpad('d/dt q_P10_SERCA in component environment (fmol)'); LEGEND_RATES(:,13) = strpad('d/dt q_P6_SERCA in component environment (fmol)'); LEGEND_RATES(:,14) = strpad('d/dt q_P8_SERCA in component environment (fmol)'); LEGEND_RATES(:,15) = strpad('d/dt q_P9_SERCA in component environment (fmol)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = 0.0057; STATES(:,2) = 2.28; STATES(:,3) = 0.004028; STATES(:,4) = 570; STATES(:,5) = 1.3794; STATES(:,6) = 3.8; STATES(:,7) = 0.11111; STATES(:,8) = 0.11111; STATES(:,9) = 0.11111; STATES(:,10) = 0.11111; STATES(:,11) = 0.11111; STATES(:,12) = 0.11111; STATES(:,13) = 0.11111; STATES(:,14) = 0.11111; STATES(:,15) = 0.11111; CONSTANTS(:,1) = 4.028E+00; CONSTANTS(:,2) = 4.028E+00; CONSTANTS(:,3) = 6.91835e-08; CONSTANTS(:,4) = 7.55655; CONSTANTS(:,5) = 8506.72; CONSTANTS(:,6) = 7.55655; CONSTANTS(:,7) = 0.241033; CONSTANTS(:,8) = 45.2524; CONSTANTS(:,9) = 6662.34; CONSTANTS(:,10) = 6662.34; CONSTANTS(:,11) = 3.65954e-06; CONSTANTS(:,12) = 45.8697; CONSTANTS(:,13) = 2.31881; CONSTANTS(:,14) = 0.242269; CONSTANTS(:,15) = 272.733; CONSTANTS(:,16) = 0.000838529; CONSTANTS(:,17) = 228.515; CONSTANTS(:,18) = 0.320649; CONSTANTS(:,19) = 0.309339; CONSTANTS(:,20) = 0.445746; CONSTANTS(:,21) = 237.968; CONSTANTS(:,22) = 0.313625; CONSTANTS(:,23) = 5.22709; CONSTANTS(:,24) = 17.0902; CONSTANTS(:,25) = 2.55479e-06; CONSTANTS(:,26) = 0.00185871; CONSTANTS(:,27) = 93.2902; CONSTANTS(:,28) = 8.31; CONSTANTS(:,29) = 310; CONSTANTS(:,30) = 96485; CONSTANTS(:,31) = 2; CONSTANTS(:,32) = 2; CONSTANTS(:,33) = 2; CONSTANTS(:,34) = 34.0; CONSTANTS(:,35) = CONSTANTS(:,34).*0.0350000; CONSTANTS(:,36) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,27).*CONSTANTS(:,1)); CONSTANTS(:,37) = CONSTANTS(:,34)+CONSTANTS(:,35); CONSTANTS(:,38) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,27).*CONSTANTS(:,2)); CONSTANTS(:,39) = CONSTANTS(:,36) - CONSTANTS(:,38); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,19) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,20).*STATES(:,12)); ALGEBRAIC(:,24) = ALGEBRAIC(:,19)+CONSTANTS(:,39); ALGEBRAIC(:,14) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,12).*STATES(:,7)); ALGEBRAIC(:,13) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,26).*STATES(:,4)); ALGEBRAIC(:,25) = ALGEBRAIC(:,14)+ALGEBRAIC(:,13)+CONSTANTS(:,39); ALGEBRAIC(:,42) = CONSTANTS(:,11).*(exp(ALGEBRAIC(:,24)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,25)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,44) = ALGEBRAIC(:,42); RATES(:,4) = ALGEBRAIC(:,44); ALGEBRAIC(:,12) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,24).*STATES(:,6)); ALGEBRAIC(:,26) = ALGEBRAIC(:,14)+ALGEBRAIC(:,12)+CONSTANTS(:,39); ALGEBRAIC(:,15) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,13).*STATES(:,8)); ALGEBRAIC(:,27) = ALGEBRAIC(:,15)+CONSTANTS(:,39); ALGEBRAIC(:,43) = CONSTANTS(:,3).*(exp(ALGEBRAIC(:,26)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,27)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,46) = - ALGEBRAIC(:,43); RATES(:,6) = ALGEBRAIC(:,46); ALGEBRAIC(:,47) = ALGEBRAIC(:,42) - ALGEBRAIC(:,43); RATES(:,7) = ALGEBRAIC(:,47); ALGEBRAIC(:,18) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,16).*STATES(:,11)); ALGEBRAIC(:,28) = ALGEBRAIC(:,18)+CONSTANTS(:,39); ALGEBRAIC(:,11) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,25).*STATES(:,5)); ALGEBRAIC(:,20) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,17).*STATES(:,13)); ALGEBRAIC(:,29) = ALGEBRAIC(:,11)+ALGEBRAIC(:,20)+CONSTANTS(:,39); ALGEBRAIC(:,45) = CONSTANTS(:,7).*(exp(ALGEBRAIC(:,28)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,29)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,49) = ALGEBRAIC(:,45); RATES(:,5) = ALGEBRAIC(:,49); ALGEBRAIC(:,10) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,21).*STATES(:,3)); ALGEBRAIC(:,30) = ALGEBRAIC(:,15)+ALGEBRAIC(:,10)+CONSTANTS(:,39); ALGEBRAIC(:,16) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,14).*STATES(:,9)); ALGEBRAIC(:,31) = ALGEBRAIC(:,16)+CONSTANTS(:,39); ALGEBRAIC(:,48) = CONSTANTS(:,5).*(exp(ALGEBRAIC(:,30)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,31)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,51) = ALGEBRAIC(:,48); RATES(:,9) = ALGEBRAIC(:,51); ALGEBRAIC(:,8) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,22).*STATES(:,1)); ALGEBRAIC(:,32) = ALGEBRAIC(:,15)+ CONSTANTS(:,31).*ALGEBRAIC(:,8)+CONSTANTS(:,39); ALGEBRAIC(:,17) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,15).*STATES(:,10)); ALGEBRAIC(:,33) = ALGEBRAIC(:,17)+CONSTANTS(:,39); ALGEBRAIC(:,50) = CONSTANTS(:,4).*(exp(ALGEBRAIC(:,32)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,33)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,52) = - CONSTANTS(:,31).*ALGEBRAIC(:,50); RATES(:,1) = ALGEBRAIC(:,52); ALGEBRAIC(:,54) = ALGEBRAIC(:,43) - ALGEBRAIC(:,50); RATES(:,8) = ALGEBRAIC(:,54); ALGEBRAIC(:,34) = ALGEBRAIC(:,17)+CONSTANTS(:,39); ALGEBRAIC(:,35) = ALGEBRAIC(:,18)+ CONSTANTS(:,33).*ALGEBRAIC(:,10)+CONSTANTS(:,39); ALGEBRAIC(:,53) = CONSTANTS(:,6).*(exp(ALGEBRAIC(:,34)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,35)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,56) = ALGEBRAIC(:,50) - ALGEBRAIC(:,53); RATES(:,10) = ALGEBRAIC(:,56); ALGEBRAIC(:,57) = ALGEBRAIC(:,53) - ALGEBRAIC(:,45); RATES(:,11) = ALGEBRAIC(:,57); ALGEBRAIC(:,36) = ALGEBRAIC(:,20)+CONSTANTS(:,39); ALGEBRAIC(:,9) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,23).*STATES(:,2)); ALGEBRAIC(:,22) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,18).*STATES(:,14)); ALGEBRAIC(:,37) = ALGEBRAIC(:,22)+ CONSTANTS(:,32).*ALGEBRAIC(:,9)+CONSTANTS(:,39); ALGEBRAIC(:,55) = CONSTANTS(:,8).*(exp(ALGEBRAIC(:,36)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,37)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,58) = CONSTANTS(:,32).*ALGEBRAIC(:,55); RATES(:,2) = ALGEBRAIC(:,58); ALGEBRAIC(:,60) = ALGEBRAIC(:,45) - ALGEBRAIC(:,55); RATES(:,13) = ALGEBRAIC(:,60); ALGEBRAIC(:,38) = ALGEBRAIC(:,22)+ CONSTANTS(:,33).*ALGEBRAIC(:,10)+CONSTANTS(:,39); ALGEBRAIC(:,23) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,19).*STATES(:,15)); ALGEBRAIC(:,39) = ALGEBRAIC(:,23)+CONSTANTS(:,39); ALGEBRAIC(:,59) = CONSTANTS(:,9).*(exp(ALGEBRAIC(:,38)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,39)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,62) = ALGEBRAIC(:,55) - ALGEBRAIC(:,59); RATES(:,14) = ALGEBRAIC(:,62); ALGEBRAIC(:,40) = ALGEBRAIC(:,23)+CONSTANTS(:,39); ALGEBRAIC(:,41) = ALGEBRAIC(:,10)+ALGEBRAIC(:,19)+CONSTANTS(:,39); ALGEBRAIC(:,61) = CONSTANTS(:,10).*(exp(ALGEBRAIC(:,40)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,41)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,63) = (( CONSTANTS(:,33).*ALGEBRAIC(:,53) - ALGEBRAIC(:,48)) - CONSTANTS(:,33).*ALGEBRAIC(:,59))+ALGEBRAIC(:,61); RATES(:,3) = ALGEBRAIC(:,63); ALGEBRAIC(:,65) = ALGEBRAIC(:,61) - ALGEBRAIC(:,42); RATES(:,12) = ALGEBRAIC(:,65); ALGEBRAIC(:,64) = ALGEBRAIC(:,59) - ALGEBRAIC(:,61); RATES(:,15) = ALGEBRAIC(:,64); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,19) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,20).*STATES(:,12)); ALGEBRAIC(:,24) = ALGEBRAIC(:,19)+CONSTANTS(:,39); ALGEBRAIC(:,14) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,12).*STATES(:,7)); ALGEBRAIC(:,13) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,26).*STATES(:,4)); ALGEBRAIC(:,25) = ALGEBRAIC(:,14)+ALGEBRAIC(:,13)+CONSTANTS(:,39); ALGEBRAIC(:,42) = CONSTANTS(:,11).*(exp(ALGEBRAIC(:,24)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,25)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,44) = ALGEBRAIC(:,42); ALGEBRAIC(:,12) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,24).*STATES(:,6)); ALGEBRAIC(:,26) = ALGEBRAIC(:,14)+ALGEBRAIC(:,12)+CONSTANTS(:,39); ALGEBRAIC(:,15) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,13).*STATES(:,8)); ALGEBRAIC(:,27) = ALGEBRAIC(:,15)+CONSTANTS(:,39); ALGEBRAIC(:,43) = CONSTANTS(:,3).*(exp(ALGEBRAIC(:,26)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,27)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,46) = - ALGEBRAIC(:,43); ALGEBRAIC(:,47) = ALGEBRAIC(:,42) - ALGEBRAIC(:,43); ALGEBRAIC(:,18) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,16).*STATES(:,11)); ALGEBRAIC(:,28) = ALGEBRAIC(:,18)+CONSTANTS(:,39); ALGEBRAIC(:,11) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,25).*STATES(:,5)); ALGEBRAIC(:,20) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,17).*STATES(:,13)); ALGEBRAIC(:,29) = ALGEBRAIC(:,11)+ALGEBRAIC(:,20)+CONSTANTS(:,39); ALGEBRAIC(:,45) = CONSTANTS(:,7).*(exp(ALGEBRAIC(:,28)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,29)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,49) = ALGEBRAIC(:,45); ALGEBRAIC(:,10) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,21).*STATES(:,3)); ALGEBRAIC(:,30) = ALGEBRAIC(:,15)+ALGEBRAIC(:,10)+CONSTANTS(:,39); ALGEBRAIC(:,16) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,14).*STATES(:,9)); ALGEBRAIC(:,31) = ALGEBRAIC(:,16)+CONSTANTS(:,39); ALGEBRAIC(:,48) = CONSTANTS(:,5).*(exp(ALGEBRAIC(:,30)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,31)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,51) = ALGEBRAIC(:,48); ALGEBRAIC(:,8) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,22).*STATES(:,1)); ALGEBRAIC(:,32) = ALGEBRAIC(:,15)+ CONSTANTS(:,31).*ALGEBRAIC(:,8)+CONSTANTS(:,39); ALGEBRAIC(:,17) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,15).*STATES(:,10)); ALGEBRAIC(:,33) = ALGEBRAIC(:,17)+CONSTANTS(:,39); ALGEBRAIC(:,50) = CONSTANTS(:,4).*(exp(ALGEBRAIC(:,32)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,33)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,52) = - CONSTANTS(:,31).*ALGEBRAIC(:,50); ALGEBRAIC(:,54) = ALGEBRAIC(:,43) - ALGEBRAIC(:,50); ALGEBRAIC(:,34) = ALGEBRAIC(:,17)+CONSTANTS(:,39); ALGEBRAIC(:,35) = ALGEBRAIC(:,18)+ CONSTANTS(:,33).*ALGEBRAIC(:,10)+CONSTANTS(:,39); ALGEBRAIC(:,53) = CONSTANTS(:,6).*(exp(ALGEBRAIC(:,34)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,35)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,56) = ALGEBRAIC(:,50) - ALGEBRAIC(:,53); ALGEBRAIC(:,57) = ALGEBRAIC(:,53) - ALGEBRAIC(:,45); ALGEBRAIC(:,36) = ALGEBRAIC(:,20)+CONSTANTS(:,39); ALGEBRAIC(:,9) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,23).*STATES(:,2)); ALGEBRAIC(:,22) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,18).*STATES(:,14)); ALGEBRAIC(:,37) = ALGEBRAIC(:,22)+ CONSTANTS(:,32).*ALGEBRAIC(:,9)+CONSTANTS(:,39); ALGEBRAIC(:,55) = CONSTANTS(:,8).*(exp(ALGEBRAIC(:,36)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,37)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,58) = CONSTANTS(:,32).*ALGEBRAIC(:,55); ALGEBRAIC(:,60) = ALGEBRAIC(:,45) - ALGEBRAIC(:,55); ALGEBRAIC(:,38) = ALGEBRAIC(:,22)+ CONSTANTS(:,33).*ALGEBRAIC(:,10)+CONSTANTS(:,39); ALGEBRAIC(:,23) = CONSTANTS(:,28).*CONSTANTS(:,29).*log( CONSTANTS(:,19).*STATES(:,15)); ALGEBRAIC(:,39) = ALGEBRAIC(:,23)+CONSTANTS(:,39); ALGEBRAIC(:,59) = CONSTANTS(:,9).*(exp(ALGEBRAIC(:,38)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,39)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,62) = ALGEBRAIC(:,55) - ALGEBRAIC(:,59); ALGEBRAIC(:,40) = ALGEBRAIC(:,23)+CONSTANTS(:,39); ALGEBRAIC(:,41) = ALGEBRAIC(:,10)+ALGEBRAIC(:,19)+CONSTANTS(:,39); ALGEBRAIC(:,61) = CONSTANTS(:,10).*(exp(ALGEBRAIC(:,40)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp(ALGEBRAIC(:,41)./( CONSTANTS(:,28).*CONSTANTS(:,29)))); ALGEBRAIC(:,63) = (( CONSTANTS(:,33).*ALGEBRAIC(:,53) - ALGEBRAIC(:,48)) - CONSTANTS(:,33).*ALGEBRAIC(:,59))+ALGEBRAIC(:,61); ALGEBRAIC(:,65) = ALGEBRAIC(:,61) - ALGEBRAIC(:,42); ALGEBRAIC(:,64) = ALGEBRAIC(:,59) - ALGEBRAIC(:,61); ALGEBRAIC(:,1) = CONSTANTS(:,31).*STATES(:,10)+ CONSTANTS(:,31).*STATES(:,11)+ CONSTANTS(:,32).*STATES(:,13); ALGEBRAIC(:,2) = STATES(:,1)./CONSTANTS(:,34); ALGEBRAIC(:,3) = STATES(:,2)./CONSTANTS(:,35); ALGEBRAIC(:,4) = STATES(:,3)./CONSTANTS(:,37); ALGEBRAIC(:,5) = STATES(:,5)./CONSTANTS(:,34); ALGEBRAIC(:,6) = STATES(:,6)./CONSTANTS(:,34); ALGEBRAIC(:,7) = STATES(:,4)./CONSTANTS(:,34); ALGEBRAIC(:,21) = CONSTANTS(:,11).*(exp(ALGEBRAIC(:,19)./( CONSTANTS(:,28).*CONSTANTS(:,29))) - exp((ALGEBRAIC(:,14)+ALGEBRAIC(:,13))./( CONSTANTS(:,28).*CONSTANTS(:,29)))); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end