function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =10; end % There are a total of 5 entries in each of the rate and state variable arrays. % There are a total of 13 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('t in component environment (second)'); LEGEND_CONSTANTS(:,1) = strpad('C_m in component environment (fF)'); LEGEND_CONSTANTS(:,2) = strpad('w_i in component environment (pL)'); LEGEND_CONSTANTS(:,3) = strpad('w_o in component environment (pL)'); LEGEND_STATES(:,1) = strpad('q_mem in component environment (fC)'); LEGEND_CONSTANTS(:,4) = strpad('R in component environment (J_per_K_per_mol)'); LEGEND_CONSTANTS(:,5) = strpad('T in component environment (kelvin)'); LEGEND_CONSTANTS(:,6) = strpad('F in component environment (C_per_mol)'); LEGEND_ALGEBRAIC(:,8) = strpad('v_pCa_R1 in component pCa (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,9) = strpad('v_pCa_R2 in component pCa (fmol_per_sec)'); LEGEND_STATES(:,2) = strpad('q_Ca_o in component environment (fmol)'); LEGEND_STATES(:,3) = strpad('q_Ca_i in component environment (fmol)'); LEGEND_STATES(:,4) = strpad('q_pCa in component environment (fmol)'); LEGEND_STATES(:,5) = strpad('q_pCa_Ca in component environment (fmol)'); LEGEND_ALGEBRAIC(:,2) = strpad('V_mem in component environment (J_per_C)'); LEGEND_ALGEBRAIC(:,10) = strpad('I_mem_pCa in component pCa (fA)'); LEGEND_ALGEBRAIC(:,3) = strpad('Ca_T in component environment (fmol)'); LEGEND_ALGEBRAIC(:,4) = strpad('channel_T in component environment (fmol)'); LEGEND_CONSTANTS(:,7) = strpad('kappa_pCa_R1 in component pCa_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,8) = strpad('kappa_pCa_R2 in component pCa_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,9) = strpad('K_Ca_i in component pCa_parameters (per_fmol)'); LEGEND_CONSTANTS(:,10) = strpad('K_Ca_o in component pCa_parameters (per_fmol)'); LEGEND_CONSTANTS(:,11) = strpad('K_pCa in component pCa_parameters (per_fmol)'); LEGEND_CONSTANTS(:,12) = strpad('K_pCa_Ca in component pCa_parameters (per_fmol)'); LEGEND_CONSTANTS(:,13) = strpad('zCa in component pCa_parameters (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('mu_Ca_i in component pCa (J_per_mol)'); LEGEND_ALGEBRAIC(:,5) = strpad('mu_Ca_o in component pCa (J_per_mol)'); LEGEND_ALGEBRAIC(:,6) = strpad('mu_pCa in component pCa (J_per_mol)'); LEGEND_ALGEBRAIC(:,7) = strpad('mu_pCa_Ca in component pCa (J_per_mol)'); LEGEND_RATES(:,3) = strpad('d/dt q_Ca_i in component environment (fmol)'); LEGEND_RATES(:,2) = strpad('d/dt q_Ca_o in component environment (fmol)'); LEGEND_RATES(:,4) = strpad('d/dt q_pCa in component environment (fmol)'); LEGEND_RATES(:,5) = strpad('d/dt q_pCa_Ca in component environment (fmol)'); LEGEND_RATES(:,1) = strpad('d/dt q_mem in component environment (fC)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 153400; CONSTANTS(:,2) = 25.8; CONSTANTS(:,3) = 3.52; STATES(:,1) = -8.5e4; CONSTANTS(:,4) = 8.31; CONSTANTS(:,5) = 310; CONSTANTS(:,6) = 96500; STATES(:,2) = 9.3276; STATES(:,3) = 0.00456; STATES(:,4) = 0.0032; STATES(:,5) = 1e-9; CONSTANTS(:,7) = 1451.43; CONSTANTS(:,8) = 0.00014695; CONSTANTS(:,9) = 32.3484; CONSTANTS(:,10) = 0.00010737; CONSTANTS(:,11) = 0.0179984; CONSTANTS(:,12) = 0.0100142; CONSTANTS(:,13) = 2; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,9).*STATES(:,3)); ALGEBRAIC(:,6) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,11).*STATES(:,4)); ALGEBRAIC(:,7) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,12).*STATES(:,5)); ALGEBRAIC(:,8) = CONSTANTS(:,7).*(exp((ALGEBRAIC(:,1)+ALGEBRAIC(:,6))./( CONSTANTS(:,4).*CONSTANTS(:,5))) - exp(ALGEBRAIC(:,7)./( CONSTANTS(:,4).*CONSTANTS(:,5)))); RATES(:,3) = - ALGEBRAIC(:,8); ALGEBRAIC(:,5) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,10).*STATES(:,2)); ALGEBRAIC(:,9) = CONSTANTS(:,8).*(exp(ALGEBRAIC(:,7)./( CONSTANTS(:,4).*CONSTANTS(:,5))) - exp((ALGEBRAIC(:,5)+ALGEBRAIC(:,6))./( CONSTANTS(:,4).*CONSTANTS(:,5)))); RATES(:,2) = ALGEBRAIC(:,9); RATES(:,4) = - ALGEBRAIC(:,8)+ALGEBRAIC(:,9); RATES(:,5) = ALGEBRAIC(:,8) - ALGEBRAIC(:,9); ALGEBRAIC(:,10) = - CONSTANTS(:,13).*CONSTANTS(:,6).*ALGEBRAIC(:,9); RATES(:,1) = ALGEBRAIC(:,10); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,9).*STATES(:,3)); ALGEBRAIC(:,6) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,11).*STATES(:,4)); ALGEBRAIC(:,7) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,12).*STATES(:,5)); ALGEBRAIC(:,8) = CONSTANTS(:,7).*(exp((ALGEBRAIC(:,1)+ALGEBRAIC(:,6))./( CONSTANTS(:,4).*CONSTANTS(:,5))) - exp(ALGEBRAIC(:,7)./( CONSTANTS(:,4).*CONSTANTS(:,5)))); ALGEBRAIC(:,5) = CONSTANTS(:,4).*CONSTANTS(:,5).*log( CONSTANTS(:,10).*STATES(:,2)); ALGEBRAIC(:,9) = CONSTANTS(:,8).*(exp(ALGEBRAIC(:,7)./( CONSTANTS(:,4).*CONSTANTS(:,5))) - exp((ALGEBRAIC(:,5)+ALGEBRAIC(:,6))./( CONSTANTS(:,4).*CONSTANTS(:,5)))); ALGEBRAIC(:,10) = - CONSTANTS(:,13).*CONSTANTS(:,6).*ALGEBRAIC(:,9); ALGEBRAIC(:,2) = STATES(:,1)./CONSTANTS(:,1); ALGEBRAIC(:,3) = STATES(:,3)+STATES(:,2)+STATES(:,5); ALGEBRAIC(:,4) = STATES(:,4)+STATES(:,5); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end