Na channel knowledge page

About

Landing page for the voltage-gated sodium potassium channel (fastNa). Other names for this protein: NaV1.1 to 1.9

The fastNa channel is thought to be made of one type of pore-forming alpha subunit, modulated by one or more beta subunits.

Subfamilies

Variants within the human species
Gene Protein
SCN1A Sodium channel protein type 1 subunit alpha
SCN2A Sodium channel protein type 2 subunit alpha
SCN3A Sodium channel protein type 3 subunit alpha
SCN4A Sodium channel protein type 4 subunit alpha
SCN5A Sodium channel protein type 5 subunit alpha
SCN8A Sodium channel protein type 8 subunit alpha
SCN9A Sodium channel protein type 9 subunit alpha
SCNAA Sodium channel protein type 10 subunit alpha
SCNBA Sodium channel protein type 11 subunit alpha
SCN1B Sodium channel subunit beta-1
SCN2B Sodium channel subunit beta-2
SCN3B Sodium channel subunit beta-3
SCN4B Sodium channel subunit beta-4

The link to the annotation (Uniprot) is provided in the first column.

Pictures

Insert

Existing models

Link to other model workspaces or exposures
Title Author
BG_fast_Na S Fong
Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ M Pan et al.

Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.

Annotations

Item Database
Gene, type 1A SCN1A (Uniprot)
Gene, type 2A SCN2A (Uniprot)
Gene, type 3A SCN3A (Uniprot)
Gene, type 4A SCN4A (Uniprot)
Gene, type 5A SCN5A (Uniprot)
Gene, type 8A SCN8A (Uniprot)
Gene, type 9A SCN9A (Uniprot)
Gene, type 10A SCNAA (Uniprot)
Gene, type 11A SCNBA (Uniprot)
Gene, type 1B SCN1B (Uniprot)
Gene, type 2B SCN2B (Uniprot)
Gene, type 3B SCN3B (Uniprot)
Gene, type 4B SCN4B (Uniprot)
Structure, type 1A SCN1A (PDB)
Structure, type 2A SCN2A (PDB)
Structure, type 3A SCN3A (PDB)
Structure, type 4A SCN4A (PDB)
Structure, type 5A SCN5A (PDB)
Structure, type 8A SCN8A (PDB)
Structure, type 9A SCN9A (AlphaFold)
Structure, type 10A SCNAA (PDB)
Structure, type 11A SCNBA (AlphaFold)
Structure, type 1B SCN1B (AlphaFold)
Structure, type 2B SCN2B (PDB)
Structure, type 3B SCN3B (PDB)
Structure, type 4B SCN4B (PDB)
Family of Na channels, alpha subunit Alpha (Interpro)
Family of Na channels, beta subunit Beta (Interpro)
Cellular component Gene Ontology
Gene activity Gene Ontology (activity)
Source
Derived from workspace Na channel knowledge page at changeset 072f58a20fb1.
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