C C There are a total of 10 entries in the algebraic variable array. C There are a total of 5 entries in each of the rate and state variable arrays. C There are a total of 21 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is Ca_m in component Ca_m (micromolar). C ALGBRC(1) is J_min in component J_min (micromolar). C ALGBRC(4) is J_mout in component J_mout (micromolar). C CONSTS(1) is k_min in component J_min (micromolar). C STATES(2) is Ca_cyt in component Ca_cyt (micromolar). C CONSTS(2) is K_m in component J_min (micromolar). C CONSTS(3) is n in component J_min (micromolar). C CONSTS(4) is k_mout in component J_mout (micromolar). C ALGBRC(7) is J_ERch in component J_ERch (micromolar). C ALGBRC(8) is J_ERpump in component J_ERpump (micromolar). C ALGBRC(9) is J_in in component J_in (micromolar). C ALGBRC(10) is J_out in component J_out (micromolar). C STATES(3) is Ca_ER in component Ca_ER (micromolar). C STATES(4) is PLC in component PLC (micromolar). C ALGBRC(2) is J_PLCact in component J_PLCact (micromolar). C ALGBRC(5) is J_PLCinact in component J_PLCinact (micromolar). C STATES(5) is G_alpha in component G_alpha (micromolar). C ALGBRC(3) is J_actG_alpha in component J_actG_alpha (micromolar). C ALGBRC(6) is J_inactG_alpha in component J_inactG_alpha (micromolar). C CONSTS(5) is k_10 in component J_ERch (dimensionless). C CONSTS(6) is K_11 in component J_ERch (dimensionless). C CONSTS(7) is K_17 in component J_ERpump (dimensionless). C CONSTS(8) is k_16 in component J_ERpump (dimensionless). C CONSTS(9) is K_12 in component J_in (dimensionless). C CONSTS(10) is k_13 in component J_in (dimensionless). C CONSTS(11) is k_14 in component J_out (dimensionless). C CONSTS(12) is K_15 in component J_out (dimensionless). C CONSTS(13) is k_7 in component J_PLCact (dimensionless). C CONSTS(14) is k_8 in component J_PLCinact (dimensionless). C CONSTS(15) is K_9 in component J_PLCinact (dimensionless). C CONSTS(16) is k_1 in component J_actG_alpha (dimensionless). C CONSTS(17) is k_2 in component J_actG_alpha (dimensionless). C CONSTS(18) is k_3 in component J_inactG_alpha (dimensionless). C CONSTS(19) is K_4 in component J_inactG_alpha (dimensionless). C CONSTS(20) is k_5 in component J_inactG_alpha (dimensionless). C CONSTS(21) is K_6 in component J_inactG_alpha (dimensionless). C RATES(1) is d/dt Ca_m in component Ca_m (micromolar). C RATES(2) is d/dt Ca_cyt in component Ca_cyt (micromolar). C RATES(3) is d/dt Ca_ER in component Ca_ER (micromolar). C RATES(4) is d/dt PLC in component PLC (micromolar). C RATES(5) is d/dt G_alpha in component G_alpha (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.1 CONSTS(1) = 330 STATES(2) = 0.01 CONSTS(2) = 1.6 CONSTS(3) = 8 CONSTS(4) = 0.5 STATES(3) = 20 STATES(4) = 0.01 STATES(5) = 0.01 CONSTS(5) = 5 CONSTS(6) = 3 CONSTS(7) = 0.05 CONSTS(8) = 5.37 CONSTS(9) = 2.8 CONSTS(10) = 13.4 CONSTS(11) = 153 CONSTS(12) = 0.16 CONSTS(13) = 2.08 CONSTS(14) = 32.24 CONSTS(15) = 29.09 CONSTS(16) = 0.01 CONSTS(17) = 0.1 CONSTS(18) = 0.64 CONSTS(19) = 0.09 CONSTS(20) = 4.88 CONSTS(21) = 1.18 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( CONSTS(1)*STATES(2) ** CONSTS(3))/(CONSTS(2) ** CONSTS(3)+STATES(2) ** CONSTS(3)) ALGBRC(4) = ( CONSTS(4)*STATES(1))/1.00000 RATES(1) = ALGBRC(1) - ALGBRC(4) ALGBRC(2) = CONSTS(13)*STATES(5) ALGBRC(5) = CONSTS(14)*(STATES(4)/(CONSTS(15)+STATES(4))) RATES(4) = (ALGBRC(2) - ALGBRC(5))*1.00000 ALGBRC(3) = CONSTS(16)+ CONSTS(17)*STATES(5) ALGBRC(6) = CONSTS(18)*STATES(4)*(STATES(5)/(CONSTS(19)+STATES(5)))+ CONSTS(20)*STATES(2)*(STATES(5)/(CONSTS(21)+STATES(5))) RATES(5) = (ALGBRC(3) - ALGBRC(6))*1.00000 ALGBRC(7) = CONSTS(5)*STATES(2)*STATES(4)*(STATES(3)/(CONSTS(6)+STATES(3))) ALGBRC(8) = CONSTS(8)*(STATES(2)/(CONSTS(7)+STATES(3))) RATES(3) = (ALGBRC(8) - ALGBRC(7))*1.00000 ALGBRC(9) = CONSTS(9)*STATES(4)+ CONSTS(10)*STATES(5) ALGBRC(10) = CONSTS(11)*(STATES(2)/(CONSTS(12)+STATES(2))) RATES(2) = (((((ALGBRC(7) - ALGBRC(8))+ALGBRC(9)) - ALGBRC(10))+ALGBRC(4)) - ALGBRC(1))*1.00000 RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = ( CONSTS(1)*STATES(2) ** CONSTS(3))/(CONSTS(2) ** CONSTS(3)+STATES(2) ** CONSTS(3)) ALGBRC(4) = ( CONSTS(4)*STATES(1))/1.00000 ALGBRC(2) = CONSTS(13)*STATES(5) ALGBRC(5) = CONSTS(14)*(STATES(4)/(CONSTS(15)+STATES(4))) ALGBRC(3) = CONSTS(16)+ CONSTS(17)*STATES(5) ALGBRC(6) = CONSTS(18)*STATES(4)*(STATES(5)/(CONSTS(19)+STATES(5)))+ CONSTS(20)*STATES(2)*(STATES(5)/(CONSTS(21)+STATES(5))) ALGBRC(7) = CONSTS(5)*STATES(2)*STATES(4)*(STATES(3)/(CONSTS(6)+STATES(3))) ALGBRC(8) = CONSTS(8)*(STATES(2)/(CONSTS(7)+STATES(3))) ALGBRC(9) = CONSTS(9)*STATES(4)+ CONSTS(10)*STATES(5) ALGBRC(10) = CONSTS(11)*(STATES(2)/(CONSTS(12)+STATES(2))) RETURN END