/* There are a total of 10 entries in the algebraic variable array. There are a total of 5 entries in each of the rate and state variable arrays. There are a total of 21 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * STATES[0] is Ca_m in component Ca_m (micromolar). * ALGEBRAIC[0] is J_min in component J_min (micromolar). * ALGEBRAIC[3] is J_mout in component J_mout (micromolar). * CONSTANTS[0] is k_min in component J_min (micromolar). * STATES[1] is Ca_cyt in component Ca_cyt (micromolar). * CONSTANTS[1] is K_m in component J_min (micromolar). * CONSTANTS[2] is n in component J_min (micromolar). * CONSTANTS[3] is k_mout in component J_mout (micromolar). * ALGEBRAIC[6] is J_ERch in component J_ERch (micromolar). * ALGEBRAIC[7] is J_ERpump in component J_ERpump (micromolar). * ALGEBRAIC[8] is J_in in component J_in (micromolar). * ALGEBRAIC[9] is J_out in component J_out (micromolar). * STATES[2] is Ca_ER in component Ca_ER (micromolar). * STATES[3] is PLC in component PLC (micromolar). * ALGEBRAIC[1] is J_PLCact in component J_PLCact (micromolar). * ALGEBRAIC[4] is J_PLCinact in component J_PLCinact (micromolar). * STATES[4] is G_alpha in component G_alpha (micromolar). * ALGEBRAIC[2] is J_actG_alpha in component J_actG_alpha (micromolar). * ALGEBRAIC[5] is J_inactG_alpha in component J_inactG_alpha (micromolar). * CONSTANTS[4] is k_10 in component J_ERch (dimensionless). * CONSTANTS[5] is K_11 in component J_ERch (dimensionless). * CONSTANTS[6] is K_17 in component J_ERpump (dimensionless). * CONSTANTS[7] is k_16 in component J_ERpump (dimensionless). * CONSTANTS[8] is K_12 in component J_in (dimensionless). * CONSTANTS[9] is k_13 in component J_in (dimensionless). * CONSTANTS[10] is k_14 in component J_out (dimensionless). * CONSTANTS[11] is K_15 in component J_out (dimensionless). * CONSTANTS[12] is k_7 in component J_PLCact (dimensionless). * CONSTANTS[13] is k_8 in component J_PLCinact (dimensionless). * CONSTANTS[14] is K_9 in component J_PLCinact (dimensionless). * CONSTANTS[15] is k_1 in component J_actG_alpha (dimensionless). * CONSTANTS[16] is k_2 in component J_actG_alpha (dimensionless). * CONSTANTS[17] is k_3 in component J_inactG_alpha (dimensionless). * CONSTANTS[18] is K_4 in component J_inactG_alpha (dimensionless). * CONSTANTS[19] is k_5 in component J_inactG_alpha (dimensionless). * CONSTANTS[20] is K_6 in component J_inactG_alpha (dimensionless). * RATES[0] is d/dt Ca_m in component Ca_m (micromolar). * RATES[1] is d/dt Ca_cyt in component Ca_cyt (micromolar). * RATES[2] is d/dt Ca_ER in component Ca_ER (micromolar). * RATES[3] is d/dt PLC in component PLC (micromolar). * RATES[4] is d/dt G_alpha in component G_alpha (micromolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.1; CONSTANTS[0] = 330; STATES[1] = 0.01; CONSTANTS[1] = 1.6; CONSTANTS[2] = 8; CONSTANTS[3] = 0.5; STATES[2] = 20; STATES[3] = 0.01; STATES[4] = 0.01; CONSTANTS[4] = 5; CONSTANTS[5] = 3; CONSTANTS[6] = 0.05; CONSTANTS[7] = 5.37; CONSTANTS[8] = 2.8; CONSTANTS[9] = 13.4; CONSTANTS[10] = 153; CONSTANTS[11] = 0.16; CONSTANTS[12] = 2.08; CONSTANTS[13] = 32.24; CONSTANTS[14] = 29.09; CONSTANTS[15] = 0.01; CONSTANTS[16] = 0.1; CONSTANTS[17] = 0.64; CONSTANTS[18] = 0.09; CONSTANTS[19] = 4.88; CONSTANTS[20] = 1.18; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[0]*pow(STATES[1], CONSTANTS[2]))/(pow(CONSTANTS[1], CONSTANTS[2])+pow(STATES[1], CONSTANTS[2])); ALGEBRAIC[3] = ( CONSTANTS[3]*STATES[0])/1.00000; RATES[0] = ALGEBRAIC[0] - ALGEBRAIC[3]; ALGEBRAIC[1] = CONSTANTS[12]*STATES[4]; ALGEBRAIC[4] = CONSTANTS[13]*(STATES[3]/(CONSTANTS[14]+STATES[3])); RATES[3] = (ALGEBRAIC[1] - ALGEBRAIC[4])*1.00000; ALGEBRAIC[2] = CONSTANTS[15]+ CONSTANTS[16]*STATES[4]; ALGEBRAIC[5] = CONSTANTS[17]*STATES[3]*(STATES[4]/(CONSTANTS[18]+STATES[4]))+ CONSTANTS[19]*STATES[1]*(STATES[4]/(CONSTANTS[20]+STATES[4])); RATES[4] = (ALGEBRAIC[2] - ALGEBRAIC[5])*1.00000; ALGEBRAIC[6] = CONSTANTS[4]*STATES[1]*STATES[3]*(STATES[2]/(CONSTANTS[5]+STATES[2])); ALGEBRAIC[7] = CONSTANTS[7]*(STATES[1]/(CONSTANTS[6]+STATES[2])); RATES[2] = (ALGEBRAIC[7] - ALGEBRAIC[6])*1.00000; ALGEBRAIC[8] = CONSTANTS[8]*STATES[3]+ CONSTANTS[9]*STATES[4]; ALGEBRAIC[9] = CONSTANTS[10]*(STATES[1]/(CONSTANTS[11]+STATES[1])); RATES[1] = (((((ALGEBRAIC[6] - ALGEBRAIC[7])+ALGEBRAIC[8]) - ALGEBRAIC[9])+ALGEBRAIC[3]) - ALGEBRAIC[0])*1.00000; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[0]*pow(STATES[1], CONSTANTS[2]))/(pow(CONSTANTS[1], CONSTANTS[2])+pow(STATES[1], CONSTANTS[2])); ALGEBRAIC[3] = ( CONSTANTS[3]*STATES[0])/1.00000; ALGEBRAIC[1] = CONSTANTS[12]*STATES[4]; ALGEBRAIC[4] = CONSTANTS[13]*(STATES[3]/(CONSTANTS[14]+STATES[3])); ALGEBRAIC[2] = CONSTANTS[15]+ CONSTANTS[16]*STATES[4]; ALGEBRAIC[5] = CONSTANTS[17]*STATES[3]*(STATES[4]/(CONSTANTS[18]+STATES[4]))+ CONSTANTS[19]*STATES[1]*(STATES[4]/(CONSTANTS[20]+STATES[4])); ALGEBRAIC[6] = CONSTANTS[4]*STATES[1]*STATES[3]*(STATES[2]/(CONSTANTS[5]+STATES[2])); ALGEBRAIC[7] = CONSTANTS[7]*(STATES[1]/(CONSTANTS[6]+STATES[2])); ALGEBRAIC[8] = CONSTANTS[8]*STATES[3]+ CONSTANTS[9]*STATES[4]; ALGEBRAIC[9] = CONSTANTS[10]*(STATES[1]/(CONSTANTS[11]+STATES[1])); }