/* There are a total of 4 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 26 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * STATES[0] is Pha in component Pha (dimensionless). * ALGEBRAIC[0] is V_1 in component V_1 (dimensionless). * STATES[1] is Z in component Z (dimensionless). * ALGEBRAIC[1] is K_1 in component K_1 (dimensionless). * CONSTANTS[0] is V_M2 in component Pha (per_minute). * CONSTANTS[1] is alpha in component Pha (dimensionless). * CONSTANTS[2] is Glc in component Pha (micromolar). * CONSTANTS[3] is K_2 in component Pha (dimensionless). * CONSTANTS[4] is K_a1 in component Pha (micromolar). * CONSTANTS[5] is K_a2 in component Pha (micromolar). * CONSTANTS[6] is V_M1 in component V_1 (per_minute). * CONSTANTS[7] is gamma in component V_1 (dimensionless). * CONSTANTS[8] is K_a5 in component V_1 (micromolar). * CONSTANTS[9] is K_11 in component K_1 (dimensionless). * CONSTANTS[10] is K_a6 in component K_1 (micromolar). * CONSTANTS[25] is V_in in component V_in (dimensionless). * ALGEBRAIC[2] is V_2i in component V_2i (dimensionless). * ALGEBRAIC[3] is V_3i in component V_3i (dimensionless). * CONSTANTS[11] is k_f in component Z (per_minute). * STATES[2] is Y in component Y (dimensionless). * CONSTANTS[12] is k in component Z (per_minute). * CONSTANTS[13] is k_f in component Y (per_minute). * CONSTANTS[14] is v_0 in component V_in (micromolar_per_minute). * CONSTANTS[15] is v_1 in component V_in (micromolar_per_minute). * CONSTANTS[16] is beta in component V_in (dimensionless). * CONSTANTS[17] is v_M2i in component V_2i (micromolar_per_minute). * CONSTANTS[18] is n in component V_2i (dimensionless). * CONSTANTS[19] is K_2i in component V_2i (micromolar). * CONSTANTS[20] is v_M3i in component V_3i (micromolar_per_minute). * CONSTANTS[21] is p in component V_3i (dimensionless). * CONSTANTS[22] is m in component V_3i (dimensionless). * CONSTANTS[23] is K_Ri in component V_3i (micromolar). * CONSTANTS[24] is K_Ai in component V_3i (micromolar). * RATES[0] is d/dt Pha in component Pha (dimensionless). * RATES[1] is d/dt Z in component Z (dimensionless). * RATES[2] is d/dt Y in component Y (dimensionless). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.098; STATES[1] = 0.000179; CONSTANTS[0] = 0.6; CONSTANTS[1] = 9; CONSTANTS[2] = 10000; CONSTANTS[3] = 0.2; CONSTANTS[4] = 10000; CONSTANTS[5] = 10000; CONSTANTS[6] = 1.5; CONSTANTS[7] = 9; CONSTANTS[8] = 0.5; CONSTANTS[9] = 0.1; CONSTANTS[10] = 0.5; CONSTANTS[11] = 0.7; STATES[2] = 0.00122; CONSTANTS[12] = 10; CONSTANTS[13] = 0.7; CONSTANTS[14] = 1; CONSTANTS[15] = 5.7; CONSTANTS[16] = 0.3; CONSTANTS[17] = 30; CONSTANTS[18] = 2; CONSTANTS[19] = 0.5; CONSTANTS[20] = 325; CONSTANTS[21] = 4; CONSTANTS[22] = 4; CONSTANTS[23] = 1.7; CONSTANTS[24] = 0.46; CONSTANTS[25] = CONSTANTS[14]+ CONSTANTS[15]*CONSTANTS[16]; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - ALGEBRAIC[0]*STATES[1]*((1.00000 - STATES[0])/(( ALGEBRAIC[1]*STATES[1]+1.00000) - STATES[0])) - ( CONSTANTS[0]*(1.00000+( CONSTANTS[1]*CONSTANTS[2])/(CONSTANTS[4]+CONSTANTS[2]))*STATES[0])/(CONSTANTS[3]/(1.00000+CONSTANTS[2]/CONSTANTS[5])+STATES[0]); resid[1] = RATES[1] - ((CONSTANTS[25] - ALGEBRAIC[2])+ALGEBRAIC[3]+ CONSTANTS[11]*STATES[2]) - CONSTANTS[12]*STATES[1]; resid[2] = RATES[2] - (ALGEBRAIC[2] - ALGEBRAIC[3]) - CONSTANTS[13]*STATES[2]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[6]*(1.00000+ CONSTANTS[7]*(pow(STATES[1], 4.00000)/pow(CONSTANTS[8], 4.00000)+pow(STATES[1], 4.00000))); ALGEBRAIC[1] = CONSTANTS[9]/(1.00000+pow(STATES[1], 4.00000)/pow(CONSTANTS[10], 4.00000)); ALGEBRAIC[2] = CONSTANTS[17]*(pow(STATES[1], CONSTANTS[18])/(pow(CONSTANTS[19], CONSTANTS[18])+pow(STATES[1], CONSTANTS[18]))); ALGEBRAIC[3] = CONSTANTS[20]*(pow(STATES[2], CONSTANTS[22])/pow(CONSTANTS[23], CONSTANTS[22])+pow(STATES[2], CONSTANTS[18]))*(pow(STATES[1], CONSTANTS[21])/(pow(CONSTANTS[24], CONSTANTS[21])+pow(STATES[1], CONSTANTS[21]))); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }