Model Mathematics

Component: environment

Component: c1

ddtimec1=0

Component: c2

ddtimec2=v13-v1+v6

Component: c3

ddtimec3=v1-2v2

Component: c4

ddtimec4=v2-v3

Component: c5

ddtimec5=v3-v7+v8

Component: c6

ddtimec6=v6-v10+v60

Component: c7

ddtimec7=v4-v5

Component: c8

ddtimec8=v7+v12-v14+v62

Component: c9

ddtimec9=v5+v107+v110+v113+v116+v119+v122+v125-v15

Component: c10

ddtimec10=v10-2v11

Component: c11

ddtimec11=v11-v12

Component: c12

ddtimec12=v15-v4+v106+v109+v112+v115+v118+v121+v124

Component: c13

ddtimec13=v61

Component: c14

ddtimec14=-v8+v14

Component: c15

ddtimec15=v8+v32+v34+v37+v39-v16+v22+v102

Component: c16

ddtimec16=-v10+v61

Component: c17

ddtimec17=v14+v79+v80+v81+v82+v102-v63+v69

Component: c18

ddtimec18=v5+v9+v63-v64

Component: c19

ddtimec19=v66+v64+v68+v105+v107-v65+v67+v80

Component: c20

ddtimec20=v65+v108+v110-v66

Component: c21

ddtimec21=v67+v111+v113-v68

Component: c22

ddtimec22=v35-v16+v24+v38+v63+v71

Component: c23

ddtimec23=v16-v4+v9+v17

Component: c24

ddtimec24=v35-v17+v25+v40+v64+v72

Component: c25

ddtimec25=v17+v19+v21-v18+v20+v34+v105+v106

Component: c26

ddtimec26=v21+v31+v68+v78-v18+v26+v65+v73

Component: c27

ddtimec27=v18-v19+v108+v109

Component: c28

ddtimec28=v19+v27-v28

Component: c29

ddtimec29=v20-v21+v111+v112

Component: c30

ddtimec30=v33+v34+v80-v35+v41+v83

Component: c31

ddtimec31=v36-v22+v69

Component: c32

ddtimec32=v22-v23+v103

Component: c33

ddtimec33=v23-v24+v37+v41+v104

Component: c34

ddtimec34=v24-v25+v39+v114+v115

Component: c35

ddtimec35=v25+v27+v31+v41-v117+v118+v26+v30+v32

Component: c36

ddtimec36=v26-v27+v120+v121

Component: c37

ddtimec37=v30-v31+v123+v124

Component: c38

ddtimec38=v32+v40+v79-v33

Component: c39

ddtimec39=v38+v39+v82-v40

Component: c40

ddtimec40=v33+v37+v81-v36+v38

Component: c41

ddtimec41=v43+v85-v28+v75

Component: c42

ddtimec42=v28-v29

Component: c43

ddtimec43=v29-v20+v30

Component: c44

ddtimec44=v43+v85-v42+v84

Component: c45

ddtimec45=v29+v45+v47-v42+v44+v46

Component: c46

ddtimec46=v42-v43

Component: c47

ddtimec47=v51+v93-v44+v86

Component: c48

ddtimec48=v44-v45

Component: c49

ddtimec49=v45+v49-v46+v50

Component: c50

ddtimec50=v46-v47

Component: c51

ddtimec51=v47+v53+v55-v48+v52+v54

Component: c52

ddtimec52=v48-v49

Component: c53

ddtimec53=v49+v51+v91+v93-v48+v50+v90+v92

Component: c54

ddtimec54=v50-v51

Component: c55

ddtimec55=v59+v101-v52+v94

Component: c56

ddtimec56=v52-v53

Component: c57

ddtimec57=v53+v57-v54+v58

Component: c58

ddtimec58=v54-v55

Component: c59

ddtimec59=v55-v56

Component: c60

ddtimec60=v57+v59+v99+v101-v56+v58+v98+v100

Component: c61

ddtimec61=v56-v57

Component: c62

ddtimec62=v58-v59

Component: c63

ddtimec63=v69+v103-v70

Component: c64

ddtimec64=v70+v104-v71+v81+v83

Component: c65

ddtimec65=v71+v114+v116-v72+v82

Component: c66

ddtimec66=v72+v74+v78+v83+v117+v119-v73+v77+v79

Component: c67

ddtimec67=v73+v120+v122-v74

Component: c68

ddtimec68=v77+v123+v125-v78

Component: c69

ddtimec69=v66+v74-v75

Component: c70

ddtimec70=v75-v76

Component: c71

ddtimec71=v76-v67+v77

Component: c72

ddtimec72=v76+v87+v89-v84+v86+v88

Component: c73

ddtimec73=v84-v85

Component: c74

ddtimec74=v86-v87

Component: c75

ddtimec75=v87+v91-v92+v88

Component: c76

ddtimec76=v88-v89

Component: c77

ddtimec77=v89+v95+v97-v90+v94+v96

Component: c78

ddtimec78=v90-v91

Component: c79

ddtimec79=v92-v93

Component: c80

ddtimec80=v94-v95

Component: c81

ddtimec81=v95+v99-v96+v100

Component: c82

ddtimec82=v96-v97

Component: c83

ddtimec83=v97-v98

Component: c84

ddtimec84=v98-v99

Component: c85

ddtimec85=v100-v101

Component: c86

ddtimec86=v60

Component: c87

ddtimec87=v62

Component: c88

ddtimec88=v106-v107

Component: c89

ddtimec89=v109-v110

Component: c90

ddtimec90=v112-v113

Component: c91

ddtimec91=v115-v116

Component: c92

ddtimec92=v118-v119

Component: c93

ddtimec93=v121-v122

Component: c94

ddtimec94=v124-v125

Component: Raf_activation

Raf_activation=c45+c46+c48+c50+c72+c73+c74+c76

Component: MEKPP_total

MEKPP_total=c51+c77

Component: ERKPP_total

ERKPP_total=c59+c83

Component: Ras_GTP_total

Ras_GTP_total=c42+c28+c70+c69

Component: ShcP_total

ShcP_total=c33+c34+c35+c36+c37+c38+c39+c40+c64+c65+c66+c67+c68+c91+c92+c93+c94

Component: EGF_EGFR_totalx2

EGF_EGFR_totalx2=2c5+c7+c8+c11+c15+c17+c18+c19+c20+c21+c23+c25+c27+c29+c32+c33+c34+c35+c36+c37+c63+c64+c65+c66+c67+c68+c88+c89+c90+c91+c92+c93+c94

Component: v1

v1=k1c1c2-kd1c3

Component: v2

v2=k2c3c3-kd2c4

Component: v3

v3=k3c4-kd3c5

Component: v4

v4=k4c23c12-kd4c7

Component: v5

v5=k5c7

Component: v6

v6=k6c2-kd6c6

Component: v7

v7=k6c5

Component: v8

v8=k8c5c14-kd8c15

Component: v9

v9=k6c23

Component: v10

v10=k10bc6c16-kd10c10

Component: v11

v11=k2c10c10-kd2c11

Component: v12

v12=k3c11-kd3c8

Component: v13

v13=k131

Component: v14

v14=k8c8c14-kd8c17

Component: v15

v15=k15c9

Component: v16

v16=k16c22c15-kd16c23

Component: v17

v17=k17c24c23-kd17c25

Component: v18

v18=k18c26c25-kd18c27

Component: v19

v19=k19c27-kd19c28c25

Component: v20

v20=k20c25c43-kd20c29

Component: v21

v21=k21c29-kd21c25c26

Component: v22

v22=k22c31c15-kd22c32

Component: v23

v23=k23c32-kd23c33

Component: v24

v24=k16c22c33-kd24c34

Component: v25

v25=k25c24c34-kd25c35

Component: v26

v26=k18c26c35-kd18c36

Component: v27

v27=k19c36-kd19c35c28

Component: v28

v28=k28c28c41-kd28c42

Component: v29

v29=k29c42-kd29c43c45

Component: v30

v30=k20c35c43-kd20c37

Component: v31

v31=k21c37-kd21c35c26

Component: v32

v32=k32c35-kd32c38c15

Component: v33

v33=k33c38-kd33c40c30

Component: v34

v34=k34c25-kd34c15c30

Component: v35

v35=k35c30-kd35c24c22

Component: v36

v36=Vm36c40Km36+c40

Component: v37

v37=k37c33-kd37c15c40

Component: v38

v38=k16c22c40-kd24c39

Component: v39

v39=k37c34-kd37c15c39

Component: v40

v40=k40c24c39-kd40c38

Component: v41

v41=k41c30c33-kd41c35

Component: v42

v42=k42c44c45-kd42c46

Component: v43

v43=k43c46

Component: v44

v44=k44c47c45-kd44c48

Component: v45

v45=k45c48

Component: v46

v46=k44c49c45-kd44c50

Component: v47

v47=k47c50

Component: v48

v48=k48c51c53-kd48c52

Component: v49

v49=k49c52

Component: v50

v50=k50c53c49-kd50c54

Component: v51

v51=k49c54

Component: v52

v52=k52c55c51-kd52c56

Component: v53

v53=k53c56

Component: v54

v54=k52c51c57-kd52c58

Component: v55

v55=k55c58

Component: v56

v56=k56c59c60-kd56c61

Component: v57

v57=k57c61

Component: v58

v58=k58c60c57-kd58c62

Component: v59

v59=k59c62

Component: v60

v60=k60c6

Component: v61

v61=k61c16

Component: v62

v62=k60c8

Component: v63

v63=k16c17c22-kd16c18

Component: v64

v64=k17c24c18-kd17c19

Component: v65

v65=k18c26c19-kd18c20

Component: v66

v66=k19c20-kd19c69c19

Component: v67

v67=k20c71c19-kd20c21

Component: v68

v68=k21c21-kd21c19c26

Component: v69

v69=k22c31c17-kd22c63

Component: v70

v70=k23c63-kd23c64

Component: v71

v71=k16c22c64-kd24c65

Component: v72

v72=k25c24c65-kd25c66

Component: v73

v73=k18c26c66-kd18c67

Component: v74

v74=k19c67-kd19c66c69

Component: v75

v75=k28c69c41-kd28c70

Component: v76

v76=k29c70-kd29c71c72

Component: v77

v77=k20c71c66-kd20c68

Component: v78

v78=k21c68-c26kd21c66

Component: v79

v79=k32c66-kd32c17c38

Component: v80

v80=k34c19-kd34c17c30

Component: v81

v81=k37c64-kd37c17c40

Component: v82

v82=k37c65-kd37c17c39

Component: v83

v83=k41c30c64-kd41c66

Component: v84

v84=k42c44c72-kd42c73

Component: v85

v85=k43c73

Component: v86

v86=k44c47c72-kd44c74

Component: v87

v87=k45c74

Component: v88

v88=k44c72c75-kd44c76

Component: v89

v89=k47c76

Component: v90

v90=k48c77c53-kd48c78

Component: v91

v91=k49c78

Component: v92

v92=k50c53c75-kd50c79

Component: v93

v93=k49c79

Component: v94

v94=k52c55c77-kd52c80

Component: v95

v95=k53c80

Component: v96

v96=k52c77c81-kd52c82

Component: v97

v97=k55c82

Component: v98

v98=k56c83c60-kd56c84

Component: v99

v99=k57c84

Component: v100

v100=k58c60c81-kd58c85

Component: v101

v101=k59c85

Component: v102

v102=k6c15-kd6c17

Component: v103

v103=k6c32-kd6c63

Component: v104

v104=k6c33-kd6c64

Component: v105

v105=k6c25-kd6c19

Component: v106

v106=k4c25c12-kd4c88

Component: v107

v107=k5c88

Component: v108

v108=k6c27-kd6c20

Component: v109

v109=k4c27c12-kd4c89

Component: v110

v110=k5c89

Component: v111

v111=k6c29-kd6c21

Component: v112

v112=k4c29c12-kd4c90

Component: v113

v113=k5c90

Component: v114

v114=k6c34-kd6c65

Component: v115

v115=k4c34c12-kd4c91

Component: v116

v116=k5c91

Component: v117

v117=k6c35-kd6c66

Component: v118

v118=k4c35c12-kd4c92

Component: v119

v119=k5c92

Component: v120

v120=k6c36-kd6c67

Component: v121

v121=k4c36c12-kd4c93

Component: v122

v122=k5c93

Component: v123

v123=k6c37-kd6c68

Component: v124

v124=k4c37c12-kd4c94

Component: v125

v125=k5c94

Component: C

C=RT1kd1k1c1+1

Component: reaction_rates

k5=1.55ifC<31000.2ifC>100000C-0.0000135+1.551otherwise