function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =13; end % There are a total of 4 entries in each of the rate and state variable arrays. % There are a total of 14 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_CONSTANTS(:,1) = strpad('stimPeriod in component stimulus_protocol_params (ms)'); LEGEND_CONSTANTS(:,2) = strpad('stimDuration in component stimulus_protocol_params (ms)'); LEGEND_CONSTANTS(:,3) = strpad('stimCurrent in component stimulus_protocol_params (uA_per_cmsq)'); LEGEND_VOI = strpad('time in component time (ms)'); LEGEND_ALGEBRAIC(:,10) = strpad('INa in component INa (uA_per_cmsq)'); LEGEND_ALGEBRAIC(:,12) = strpad('IK in component IK (uA_per_cmsq)'); LEGEND_ALGEBRAIC(:,13) = strpad('Ileak in component Ileak (uA_per_cmsq)'); LEGEND_STATES(:,1) = strpad('V in component action_potential (mV)'); LEGEND_ALGEBRAIC(:,1) = strpad('minus_V in component action_potential (mV)'); LEGEND_STATES(:,2) = strpad('X in component hh_gating_variable (dimensionless)'); LEGEND_STATES(:,3) = strpad('X in component hh_gating_variable (dimensionless)'); LEGEND_STATES(:,4) = strpad('X in component hh_gating_variable (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('V_initial in component initial_conditions (mV)'); LEGEND_CONSTANTS(:,5) = strpad('n_initial in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,6) = strpad('m_initial in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,7) = strpad('h_initial in component initial_conditions (dimensionless)'); LEGEND_ALGEBRAIC(:,2) = strpad('IStim in component stimulus_protocol (uA_per_cmsq)'); LEGEND_CONSTANTS(:,8) = strpad('VNa in component parameters (mV)'); LEGEND_CONSTANTS(:,9) = strpad('VK in component parameters (mV)'); LEGEND_CONSTANTS(:,10) = strpad('Vleak in component parameters (mV)'); LEGEND_CONSTANTS(:,11) = strpad('gNa_max in component parameters (mS_per_cmsq)'); LEGEND_CONSTANTS(:,12) = strpad('gK_max in component parameters (mS_per_cmsq)'); LEGEND_CONSTANTS(:,13) = strpad('gleak_max in component parameters (mS_per_cmsq)'); LEGEND_CONSTANTS(:,14) = strpad('Cm in component parameters (uF_per_cmsq)'); LEGEND_ALGEBRAIC(:,6) = strpad('gNa in component INa (mS_per_cmsq)'); LEGEND_ALGEBRAIC(:,11) = strpad('gK in component IK (mS_per_cmsq)'); LEGEND_ALGEBRAIC(:,3) = strpad('alpha in component alpha_m (per_ms)'); LEGEND_ALGEBRAIC(:,7) = strpad('beta in component beta_m (per_ms)'); LEGEND_ALGEBRAIC(:,4) = strpad('alpha in component alpha_h (per_ms)'); LEGEND_ALGEBRAIC(:,8) = strpad('beta in component beta_h (per_ms)'); LEGEND_ALGEBRAIC(:,5) = strpad('alpha in component alpha_n (per_ms)'); LEGEND_ALGEBRAIC(:,9) = strpad('beta in component beta_n (per_ms)'); LEGEND_RATES(:,1) = strpad('d/dt V in component action_potential (mV)'); LEGEND_RATES(:,3) = strpad('d/dt X in component hh_gating_variable (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt X in component hh_gating_variable (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt X in component hh_gating_variable (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 50; CONSTANTS(:,2) = 0.5; CONSTANTS(:,3) = -10.0; CONSTANTS(:,4) = 0.0; CONSTANTS(:,5) = 0.315; CONSTANTS(:,6) = 0.042; CONSTANTS(:,7) = 0.608; CONSTANTS(:,8) = -115.0; CONSTANTS(:,9) = 12.0; CONSTANTS(:,10) = -10.613; CONSTANTS(:,11) = 120.0; CONSTANTS(:,12) = 36.0; CONSTANTS(:,13) = 0.3; CONSTANTS(:,14) = 1.0; STATES(:,1) = CONSTANTS(:,4); STATES(:,2) = CONSTANTS(:,7); STATES(:,3) = CONSTANTS(:,6); STATES(:,4) = CONSTANTS(:,5); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,3) = ( 0.100000.*(STATES(:,1)+25.0000))./(exp((STATES(:,1)+25.0000)./10.0000) - 1.00000); ALGEBRAIC(:,7) = 4.00000.*exp(STATES(:,1)./18.0000); RATES(:,3) = ALGEBRAIC(:,3).*(1.00000 - STATES(:,3)) - ALGEBRAIC(:,7).*STATES(:,3); ALGEBRAIC(:,4) = 0.0700000.*exp(STATES(:,1)./20.0000); ALGEBRAIC(:,8) = 1.00000./(exp((STATES(:,1)+30.0000)./10.0000)+1.00000); RATES(:,2) = ALGEBRAIC(:,4).*(1.00000 - STATES(:,2)) - ALGEBRAIC(:,8).*STATES(:,2); ALGEBRAIC(:,5) = ( 0.0100000.*(STATES(:,1)+10.0000))./(exp((STATES(:,1)+10.0000)./10.0000) - 1.00000); ALGEBRAIC(:,9) = 0.125000.*exp(STATES(:,1)./80.0000); RATES(:,4) = ALGEBRAIC(:,5).*(1.00000 - STATES(:,4)) - ALGEBRAIC(:,9).*STATES(:,4); ALGEBRAIC(:,6) = CONSTANTS(:,11).*power(STATES(:,3), 3.00000).*STATES(:,2); ALGEBRAIC(:,10) = ALGEBRAIC(:,6).*(STATES(:,1) - CONSTANTS(:,8)); ALGEBRAIC(:,11) = CONSTANTS(:,12).*power(STATES(:,4), 4.00000); ALGEBRAIC(:,12) = ALGEBRAIC(:,11).*(STATES(:,1) - CONSTANTS(:,9)); ALGEBRAIC(:,13) = CONSTANTS(:,13).*(STATES(:,1) - CONSTANTS(:,10)); ALGEBRAIC(:,2) = piecewise({ rem(VOI, CONSTANTS(:,1)) req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end