/* There are a total of 7 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 16 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is tau in component membrane (millisecond). * ALGEBRAIC[4] is i_K in component potassium_current (picoA). * ALGEBRAIC[6] is i_K_ATP in component ATP_sensitive_potassium_current (picoA). * ALGEBRAIC[3] is i_Ca in component calcium_current (picoA). * ALGEBRAIC[5] is i_s in component slow_current (picoA). * CONSTANTS[1] is g_Ca in component calcium_current (nanoS). * CONSTANTS[2] is V_Ca in component calcium_current (millivolt). * ALGEBRAIC[0] is m_infinity in component calcium_current_m_gate (dimensionless). * CONSTANTS[3] is V_m in component calcium_current_m_gate (millivolt). * CONSTANTS[4] is theta_m in component calcium_current_m_gate (millivolt). * CONSTANTS[5] is V_K in component potassium_current (millivolt). * CONSTANTS[6] is g_K in component potassium_current (nanoS). * STATES[1] is n in component potassium_current_n_gate (dimensionless). * ALGEBRAIC[1] is n_infinity in component potassium_current_n_gate (dimensionless). * CONSTANTS[7] is V_n in component potassium_current_n_gate (millivolt). * CONSTANTS[8] is theta_n in component potassium_current_n_gate (millivolt). * CONSTANTS[9] is lambda in component potassium_current_n_gate (dimensionless). * CONSTANTS[10] is g_s in component slow_current (nanoS). * STATES[2] is s in component slow_current_s_gate (dimensionless). * ALGEBRAIC[2] is s_infinity in component slow_current_s_gate (dimensionless). * CONSTANTS[11] is V_s in component slow_current_s_gate (millivolt). * CONSTANTS[12] is theta_s in component slow_current_s_gate (millivolt). * CONSTANTS[13] is tau_s in component slow_current_s_gate (millisecond). * CONSTANTS[14] is g_K_ATP in component ATP_sensitive_potassium_current (nanoS). * CONSTANTS[15] is p in component ATP_sensitive_potassium_current (dimensionless). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[1] is d/dt n in component potassium_current_n_gate (dimensionless). * RATES[2] is d/dt s in component slow_current_s_gate (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -64.0; CONSTANTS[0] = 20.0; CONSTANTS[1] = 3.6; CONSTANTS[2] = 25.0; CONSTANTS[3] = -20.0; CONSTANTS[4] = 12.0; CONSTANTS[5] = -75.0; CONSTANTS[6] = 10.0; STATES[1] = 0.01; CONSTANTS[7] = -17.0; CONSTANTS[8] = 5.6; CONSTANTS[9] = 0.9; CONSTANTS[10] = 4.0; STATES[2] = 0.01; CONSTANTS[11] = -22.0; CONSTANTS[12] = 8.0; CONSTANTS[13] = 20000.0; CONSTANTS[14] = 1.2; CONSTANTS[15] = 0.5; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((CONSTANTS[7] - STATES[0])/CONSTANTS[8])); RATES[1] = ( CONSTANTS[9]*(ALGEBRAIC[1] - STATES[1]))/CONSTANTS[0]; ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[11] - STATES[0])/CONSTANTS[12])); RATES[2] = (ALGEBRAIC[2] - STATES[2])/CONSTANTS[13]; ALGEBRAIC[4] = CONSTANTS[6]*STATES[1]*(STATES[0] - CONSTANTS[5]); ALGEBRAIC[6] = CONSTANTS[14]*CONSTANTS[15]*(STATES[0] - CONSTANTS[5]); ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[3] - STATES[0])/CONSTANTS[4])); ALGEBRAIC[3] = CONSTANTS[1]*ALGEBRAIC[0]*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[5] = CONSTANTS[10]*STATES[2]*(STATES[0] - CONSTANTS[5]); RATES[0] = - (ALGEBRAIC[3]+ALGEBRAIC[4]+ALGEBRAIC[6]+ALGEBRAIC[5])/CONSTANTS[0]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 1.00000/(1.00000+exp((CONSTANTS[7] - STATES[0])/CONSTANTS[8])); ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[11] - STATES[0])/CONSTANTS[12])); ALGEBRAIC[4] = CONSTANTS[6]*STATES[1]*(STATES[0] - CONSTANTS[5]); ALGEBRAIC[6] = CONSTANTS[14]*CONSTANTS[15]*(STATES[0] - CONSTANTS[5]); ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[3] - STATES[0])/CONSTANTS[4])); ALGEBRAIC[3] = CONSTANTS[1]*ALGEBRAIC[0]*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[5] = CONSTANTS[10]*STATES[2]*(STATES[0] - CONSTANTS[5]); }