Chang and Fujita's 1999 kinetic model of the thiazide-sensitive Na-Cl cotransporter of the renal distal tubule.
Renal Distal Tubule
The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
The model runs in the PCEnv simulator but gives a flat output.
ENa
Extracellular Transporter-Sodium Complex
A kinetic model of the thiazide-sensitive Na-Cl cotransporter
F959
276
F952
Intracellular Transporter
E_
kidney
electrophysiology
Extracellular Transporter-Thiazide Diuretics Complex
ED
Removed reaction element and replaced with simple MathML
This is the CellML description of Chang and Fujita's 1999 kinetic model of the thiazide-sensitive Na-Cl cotransporter of the renal distal tubule. This model can be run in PCEnv but it gives a flat output. I suspect it needs to be embedded within a whole cell model in order to give a reasonable output.
Catherine
Lloyd
May
Intracellular Transporter-Sodium-Chloride Complex
ENaCl_i
Intracellular Transporter-Thiazide Diuretics Complex
ED_
c.lloyd@auckland.ac.nz
The University of Auckland, Auckland Bioengineering Institute
Chang
Hangil
Extracellular Transporter-Chloride Complex
ECl
The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
2007-05-28T00:00:00+00:00
keyword
Lloyd
May
Catherine
Fujita
Toshiro
Extracellular Transporter-Sodium-Chloride Complex
ENaCl
Extracellular Transporter-Thiazide Diuretics-Sodium Complex
ENaD
Intracellular Transporter-Chloride Complex
ECl_
American Journal of Physiology
ENa_
Intracellular Transporter-Sodium Complex
2007-06-05T09:16:58+12:00
1999-06
ENaD_
Intracellular Transporter-Thiazide Diuretics-Sodium Complex
Extracellular Transporter
E
The University of Auckland
Auckland Bioengineering Institute
Catherine Lloyd
Catherine Lloyd
10362783
2007-06-25T13:20:00+12:00